HitPredict

Interactor 1: SNX2 (O60749)
Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9)
Gene: SNX2

Interactor 2: SNX32 (Q86XE0)
Sorting nexin-32 (Sorting nexin-6B)
Gene: SNX32

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	28514442, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, validated two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PX~PX, PX~Vps5, Vps5~Vps5
Common GO terms	GO:0005768 - endosome GO:0005829 - cytosol GO:0035091 - phosphatidylinositol binding GO:0042147 - retrograde transport, endosome to Golgi
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 519 Hs			1 403
+	Hs
		240464 SNX2_HUMAN (1-519): 5.7e-150: 440: 100.00		SNX5_HUMAN (10-400): 2.41e-108: 326: 62.40
+	Hs
		240456 SNX2_HUMAN (1-519): 5.7e-150: 440: 100.00		SNX6_HUMAN (14-402): 3.69e-106: 320: 69.67
+	Hs
		240317 SNX2_HUMAN (1-519): 5.7e-150: 440: 100.00		SNX2_HUMAN (15-401): 1.09e-95: 297: 22.74
+	Hs
		1040476 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		SNX32_HUMAN (1-403): 5.67e-117: 348: 100.00
+	Hs
		240386 SNX2_HUMAN (1-519): 5.7e-150: 440: 100.00		SNX1_HUMAN (26-401): 5.84e-89: 280: 22.42
+	Hs
		1040543 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		SNX5_HUMAN (10-400): 2.41e-108: 326: 62.40
+	Hs
		1040533 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		SNX6_HUMAN (14-402): 3.69e-106: 320: 69.67
+	Dm
		1370164 Q9VQQ6_DROME (76-518): 6.16e-110: 336: 46.12		Q9VLQ9_DROME (18-400): 7.72e-105: 318: 55.09
+	Hs
		1040456 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		SNX1_HUMAN (26-401): 5.84e-89: 280: 22.42
+	Dm
		112640 X2J8I7_DROME (76-518): 1.68e-107: 330: 45.90		M9NDI3_DROME (18-400): 4.17e-102: 312: 54.50
+	Hs
		240322 SNX2_HUMAN (1-519): 5.7e-150: 440: 100.00		SNX4_HUMAN (26-397): 6.98e-52: 181: 14.76
+	Ce
		90270 Q9GYJ9_CAEEL (47-518): 4.39e-96: 301: 35.55		D9PTP5_CAEEL (15-401): 3.37e-95: 294: 49.49
+	Hs
		1261054 SNX9_HUMAN (3-515): 6.14e-93: 296: 16.64		SNX33_HUMAN (2-400): 1.06e-86: 276: 13.53
+	At
		82561 SNX2B_ARATH (1-518): 5.96e-93: 296: 22.99		SNX1_ARATH (1-401): 7.88e-84: 263: 18.74
+	Hs
		1040542 SNX1_HUMAN (2-519): 1.54e-123: 373: 59.32		SNX8_HUMAN (33-399): 3.46e-53: 185: 16.63
+	At
		82560 SNX2B_ARATH (1-518): 5.96e-93: 296: 22.99		SNX2A_ARATH (25-399): 7.29e-72: 237: 15.17
+	At
		82559 SNX2B_ARATH (1-518): 5.96e-93: 296: 22.99		SNX2B_ARATH (25-400): 8.11e-71: 234: 14.54
+	Ce
		1325795 Q9GYJ9_CAEEL (47-518): 4.39e-96: 301: 35.55		Q9GYJ9_CAEEL (36-400): 3.82e-69: 227: 18.18
+	Ce
		90278 Q9GYJ9_CAEEL (47-518): 4.39e-96: 301: 35.55		D9PTP8_CAEEL (271-401): 1.41e-36: 131: 51.91