HitPredict - High confidence protein-protein interactions

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.55	0.708

Property	Details
Experiments	11588587, 16714300, 25861987, 18195004, 39079530, 19651786, 32814053
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003779 - actin binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion and 18 others more... GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0008344 - adult locomotory behavior GO:0009410 - response to xenobiotic stimulus GO:0014059 - regulation of dopamine secretion GO:0030544 - Hsp70 protein binding GO:0030672 - synaptic vesicle membrane GO:0031648 - protein destabilization GO:0034599 - cellular response to oxidative stress GO:0043025 - neuronal cell body GO:0043065 - positive regulation of apoptotic process GO:0043195 - terminal bouton GO:0043274 - phospholipase binding GO:0043524 - negative regulation of neuron apoptotic process GO:0048471 - perinuclear region of cytoplasm GO:0051583 - dopamine uptake involved in synaptic transmission GO:1990000 - amyloid fibril formation
Homologous interactions	0

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Last updated: 11Aug2025