HitPredict

Interactor 1: H2B1K (O60814)
Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1)
Gene: H2BC12

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	36517590, 34349018
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~preSET_CXC, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 746
+	Hs
		1079994 H2B2E_HUMAN (1-126): 5.55e-54: 166: 98.41		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080205 H2B1H_HUMAN (1-126): 5.43e-54: 166: 98.41		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		918389 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		331768 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		331825 H2B2E_HUMAN (1-126): 5.55e-54: 166: 98.41		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		1087342 H2B2E_HUMAN (1-126): 5.55e-54: 166: 98.41		NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82
+	Hs
		1274410 H2B1H_HUMAN (1-126): 5.43e-54: 166: 98.41		NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82
+	Hs
		918612 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82
+	Hs
		1087410 H2B2E_HUMAN (1-126): 5.55e-54: 166: 98.41		EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27
+	Hs
		918699 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27
+	Hs
		1087385 H2B2E_HUMAN (1-126): 5.55e-54: 166: 98.41		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42
+	Hs
		918663 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42
+	Hs
		1087341 H2B2E_HUMAN (1-126): 5.55e-54: 166: 98.41		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	Hs
		918611 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	Hs
		203602 H2B1K_HUMAN (1-126): 1.2e-53: 166: 100.00		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	Hs
		1274453 H2B1H_HUMAN (1-126): 5.43e-54: 166: 98.41		ASH1L_HUMAN (547-732): 3.87e-57: 214: 30.85
+	Hs
		241509 H2B1K_HUMAN (1-126): 1.2e-53: 166: 100.00		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		918303 H2B1C_HUMAN (1-126): 1.07e-53: 166: 99.21		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		975269 H2B2E_HUMAN (1-126): 5.55e-54: 166: 98.41		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		165638 H2B1B_HUMAN (1-126): 1.52e-53: 165: 96.83		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71