HitPredict

Interactor 1: DKC1 (O60832)
H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)
Gene: DKC1

Interactor 2: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 514 Hs			1 344
+	Hs
		242440 DKC1_HUMAN (1-514): 0: 779: 100.00		SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65
+	Hs
		242559 DKC1_HUMAN (1-514): 0: 779: 100.00		RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05
+	Hs
		242441 DKC1_HUMAN (1-514): 0: 779: 100.00		SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47
+	Hs
		242447 DKC1_HUMAN (1-514): 0: 779: 100.00		SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25
+	Hs
		242551 DKC1_HUMAN (1-514): 0: 779: 100.00		RBM4B_HUMAN (1-343): 2.62e-45: 160: 18.23
+	Hs
		242428 DKC1_HUMAN (1-514): 0: 779: 100.00		SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84
+	Sc
		376706 CBF5_YEAST (33-472): 0: 633: 63.17		PABP_YEAST (99-194): 1.33e-11: 67.6: 19.80