HitPredict

Interactor 1: DKC1 (O60832)
H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)
Gene: DKC1

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.739

Property	Details
Experiments	28514442, 28561026, 33961781, 18358808, 26186194, 19179534
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:1904874 - positive regulation of telomerase RNA localization to Cajal body
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 514 Hs			1 456
+	Hs
		242605 DKC1_HUMAN (1-514): 0: 779: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sc
		704415 CBF5_YEAST (33-472): 0: 633: 63.17		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		704456 CBF5_YEAST (33-472): 0: 633: 63.17		RUVB2_YEAST (5-455): 0: 627: 41.72