HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.894

Property	Details
Experiments	12458214, 12545174, 16983070, 25416956
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, mammalian protein protein interaction trap
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0002250 - adaptive immune response GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 128 Hs			1 537
+	Hs
		412070 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		FYN_HUMAN (1-537): 0: 643: 100.00
+	Hs
		337307 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		FYN_HUMAN (1-537): 0: 643: 100.00
+	Hs
		442772 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		SRC_HUMAN (1-537): 0: 598: 68.21
+	Hs
		522840 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		SRC_HUMAN (1-537): 0: 598: 68.21
+	Hs
		337329 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		SRC_HUMAN (1-537): 0: 598: 68.21
+	Hs
		411559 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		LCK_HUMAN (40-535): 0: 551: 57.60
+	Hs
		442759 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		HCK_HUMAN (1-535): 0: 548: 56.64
+	Mm
		435875 HCK_MOUSE (1-127): 9.56e-42: 145: 19.55		HCK_MOUSE (1-535): 0: 542: 56.45
+	Hs
		433530 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		442789 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL2_HUMAN (7-537): 2.06e-170: 515: 38.09
+	Hs
		789042 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL2_HUMAN (7-537): 2.06e-170: 515: 38.09
+	Hs
		337315 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56
+	Hs
		337384 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56
+	Hs
		337293 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56
+	Mm
		337615 ABL1_MOUSE (1-127): 5.17e-40: 143: 26.72		ABL1_MOUSE (42-537): 4.1e-167: 504: 39.56
+	Hs
		442813 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		BTK_HUMAN (5-531): 1.1e-153: 456: 31.02
+	Hs
		337440 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		BTK_HUMAN (5-531): 1.1e-153: 456: 31.02