HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.619

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 1390
+	Hs
		441403 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		441462 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		411558 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		337359 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13
+	Hs
		789049 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20
+	Mm
		337625 ABL1_MOUSE (1-127): 5.17e-40: 143: 26.72		EPHA4_MOUSE (555-1389): 1.3e-175: 550: 17.08
+	Hs
		665558 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91
+	Hs
		337360 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91
+	Hs
		789068 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53
+	Hs
		789048 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72
+	Hs
		674354 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90
+	Hs
		411613 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90
+	Hs
		789061 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		TYRO3_HUMAN (1053-1341): 6.19e-65: 240: 41.67
+	Hs
		337441 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		TYRO3_HUMAN (1053-1341): 6.19e-65: 240: 41.67
+	Hs
		442833 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75
+	Hs
		337315 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38
+	Hs
		789067 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75
+	Hs
		337384 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38
+	Hs
		337480 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75
+	Hs
		337293 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38