HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007267 - cell-cell signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 920
+	Hs
		442764 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		487203 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		337320 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		411564 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		433225 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		433537 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		487088 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		454790 FGR_HUMAN (1-126): 6.18e-38: 135: 20.30		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		487245 BLK_HUMAN (1-125): 7.14e-38: 135: 18.46		ANDR_HUMAN (1-920): 0: 966: 100.00
+	Hs
		368834 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Hs
		368894 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20
+	Rn
		411266 SRC_RAT (1-127): 6.14e-39: 138: 20.90		ESR1_RAT (378-904): 2.19e-130: 406: 20.94
+	Mm
		403414 SRC_MOUSE (1-127): 8.71e-39: 138: 20.90		ESR1_MOUSE (378-904): 2.5e-129: 403: 21.30
+	Hs
		377006 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		377057 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		GCR_HUMAN (444-920): 1.2e-117: 378: 40.85
+	Hs
		522762 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		RXRA_HUMAN (392-902): 7.05e-120: 374: 19.84
+	Hs
		433435 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		523091 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51
+	Hs
		414427 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		PRGR_HUMAN (469-920): 4.71e-106: 352: 45.73
+	Hs
		487890 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		RARA_HUMAN (460-902): 8.57e-110: 348: 19.87