HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 128 Hs			1 377
+	Hs
		557630 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00
+	Hs
		209001 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		442789 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05
+	Hs
		789042 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05
+	Hs
		298959 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26
+	Hs
		442782 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		298944 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26
+	Hs
		655254 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		129173 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Mm
		411918 LCK_MOUSE (1-125): 7.28e-41: 143: 19.08		P85A_MOUSE (241-376): 1.59e-22: 101: 19.57
+	Hs
		129151 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		412070 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		442759 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		337307 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		337315 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		442772 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		522840 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		789054 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		442869 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76