HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: CD22 (P20273)
B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)
Gene: CD22

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	19150402
Identification Methods	pull down, peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0050776 - regulation of immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 847
+	Hs
		433569 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		CD22_HUMAN (19-847): 0: 566: 100.00
+	Hs
		590610 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		CD22_HUMAN (19-847): 0: 566: 100.00
+	Hs
		590607 GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69		CD22_HUMAN (19-847): 0: 566: 100.00
+	Mm
		722908 SHIP1_MOUSE (4-103): 9.63e-37: 133: 42.00		CD22_MOUSE (1-847): 4.34e-170: 516: 57.29
+	Mm
		722901 GRB2_MOUSE (1-123): 1.02e-35: 123: 19.69		CD22_MOUSE (1-847): 4.34e-170: 516: 57.29
+	Mm
		722897 KSYK_MOUSE (5-120): 2.79e-15: 72.8: 24.79		CD22_MOUSE (1-847): 4.34e-170: 516: 57.29
+	Hs
		433742 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		PTK7_HUMAN (17-789): 6.28e-108: 358: 15.04
+	Hs
		924478 GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69		PGBM_HUMAN (9-835): 1.01e-85: 302: 15.22
+	Hs
		433947 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		KIRR1_HUMAN (3-500): 6.45e-54: 202: 20.38
+	Hs
		924791 GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69		KIRR1_HUMAN (3-500): 6.45e-54: 202: 20.38
+	Hs
		235232 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		NPHN_HUMAN (12-522): 3.31e-38: 156: 19.07
+	Hs
		235231 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		NPHN_HUMAN (12-522): 3.31e-38: 156: 19.07
+	Hs
		433249 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		VCAM1_HUMAN (420-769): 2.41e-30: 130: 17.62
+	Hs
		412004 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		MAG_HUMAN (153-541): 1.61e-32: 136: 20.28
+	Hs
		176379 SHIP2_HUMAN (3-122): 1.12e-34: 128: 37.50		VCAM1_HUMAN (420-769): 2.41e-30: 130: 17.62
+	Hs
		581649 GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69		VCAM1_HUMAN (420-769): 2.41e-30: 130: 17.62
+	Hs
		177593 SH21A_HUMAN (1-128): 3.11e-38: 127: 100.00		SIGL5_HUMAN (251-611): 2.47e-19: 94.5: 17.38
+	Hs
		433804 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		SDK2_HUMAN (119-834): 2.36e-13: 76.6: 10.52
+	Hs
		243162 SH21A_HUMAN (1-128): 3.11e-38: 127: 100.00		SIGL7_HUMAN (89-316): 9.13e-17: 85.9: 29.32
+	Hs
		581520 KSYK_HUMAN (6-120): 2.74e-15: 72.8: 25.86		VCAM1_HUMAN (420-769): 2.41e-30: 130: 17.62