HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 1308
+	Hs
		442833 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ERBB4_HUMAN (1-1308): 0: 1406: 100.00
+	Hs
		789067 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ERBB4_HUMAN (1-1308): 0: 1406: 100.00
+	Hs
		442779 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		601837 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		337346 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383547 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		383673 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		337300 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		337804 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		338083 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		337294 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		337315 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL1_HUMAN (693-1305): 3.03e-121: 406: 25.00
+	Hs
		337384 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL1_HUMAN (693-1305): 3.03e-121: 406: 25.00
+	Hs
		337293 ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72		ABL1_HUMAN (693-1305): 3.03e-121: 406: 25.00
+	Hs
		665558 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		EPHB2_HUMAN (647-987): 4.64e-116: 390: 34.45
+	Hs
		442812 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		FAK1_HUMAN (703-997): 6.55e-59: 223: 39.53
+	Hs
		442789 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ABL2_HUMAN (713-980): 1.37e-55: 214: 42.59
+	Hs
		789042 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		ABL2_HUMAN (713-980): 1.37e-55: 214: 42.59
+	Hs
		442817 HCK_HUMAN (1-127): 3.37e-42: 147: 20.30		ACK1_HUMAN (697-970): 1.51e-54: 209: 40.43
+	Mm
		411920 LCK_MOUSE (1-125): 7.28e-41: 143: 19.08		ZAP70_MOUSE (724-967): 2.11e-55: 206: 42.45