HitPredict

Interactor 1: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Interactor 2: SLAF5 (Q9UIB8)
SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
Gene: CD84

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.738

Property	Details
Experiments	12115647, 12928397, 11389028, 11477068, 19150402, 12163025, 12225753
Identification Methods	affinity chromatography technology, peptide array, two hybrid, coimmunoprecipitation, nuclear magnetic resonance
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002250 - adaptive immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 345
+	Hs
		789096 ABL2_HUMAN (1-127): 9.79e-41: 145: 27.48		SLAF5_HUMAN (1-345): 4.82e-70: 224: 100.00
+	Hs
		433317 YES_HUMAN (1-127): 2.68e-40: 142: 19.40		CXAR_HUMAN (1-328): 8.07e-54: 182: 13.28
+	Hs
		433691 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		CXAR_HUMAN (1-328): 8.07e-54: 182: 13.28
+	Hs
		411818 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		SLAF6_HUMAN (3-345): 1.05e-52: 178: 26.00
+	Hs
		411561 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		CD48_HUMAN (21-239): 8.24e-47: 160: 18.67
+	Hs
		1030743 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		SLAF1_HUMAN (4-323): 1.91e-47: 165: 18.45
+	Hs
		454828 FGR_HUMAN (1-126): 6.18e-38: 135: 20.30		SLAF1_HUMAN (4-323): 1.91e-47: 165: 18.45
+	Hs
		523015 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		CEA21_HUMAN (8-285): 9.6e-47: 161: 17.53
+	Hs
		412176 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		SLAF1_HUMAN (4-323): 1.91e-47: 165: 18.45
+	Mm
		1322348 SHIP1_MOUSE (4-103): 9.63e-37: 133: 42.00		SLAF1_MOUSE (3-323): 1.24e-46: 163: 16.77
+	Hs
		411547 LCK_HUMAN (1-125): 4.76e-41: 143: 19.08		CD2_HUMAN (2-342): 4.75e-43: 153: 18.57
+	Mm
		763408 FYN_MOUSE (1-125): 4.62e-37: 133: 18.52		SLAF1_MOUSE (3-323): 1.24e-46: 163: 16.77
+	Hs
		411939 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		CD2_HUMAN (2-342): 4.75e-43: 153: 18.57
+	Hs
		523136 SRC_HUMAN (1-127): 8.71e-39: 138: 20.90		CD244_HUMAN (44-344): 4.75e-40: 146: 21.09
+	Hs
		1271565 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		CD244_HUMAN (44-344): 4.75e-40: 146: 21.09
+	Hs
		1271567 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		SLAF7_HUMAN (5-345): 2.26e-40: 146: 28.37
+	Hs
		412347 FYN_HUMAN (1-125): 4.91e-37: 133: 18.52		CD244_HUMAN (44-344): 4.75e-40: 146: 21.09
+	Hs
		176495 SHIP2_HUMAN (3-122): 1.12e-34: 128: 37.50		CD244_HUMAN (44-344): 4.75e-40: 146: 21.09
+	Hs
		434111 LYN_HUMAN (1-125): 1.04e-39: 140: 19.85		ROBO1_HUMAN (14-332): 2.51e-33: 132: 13.86
+	Hs
		1271566 SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00		LY9_HUMAN (13-254): 6.07e-34: 133: 29.84