HitPredict

Interactor 1: DNJA2 (O60884)
DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14)
Gene: DNAJA2

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.666

Property	Details
Experiments	24797263, 23956138, 15657067, 24189400
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0008284 - positive regulation of cell population proliferation GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 1210
+	Hs
		338003 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		243250 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		338830 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		339080 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		383639 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		601821 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		383929 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		384016 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		602017 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		243261 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		243254 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		411313 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		434302 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		411469 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		411515 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		243262 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47
+	Hs
		435551 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47
+	Hs
		537779 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90
+	Hs
		435729 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47
+	Hs
		435790 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47