HitPredict

Interactor 1: DNJA2 (O60884)
DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14)
Gene: DNAJA2

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35384245, 24189400
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0008284 - positive regulation of cell population proliferation GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 1255
+	Hs
		383639 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		383929 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		384016 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		243241 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		338003 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		601821 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		338830 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		339080 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		243261 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		RET_HUMAN (426-1088): 3.53e-131: 432: 23.33
+	Hs
		243254 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		411313 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		238430 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75
+	Hs
		434302 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		RET_HUMAN (426-1088): 3.53e-131: 432: 23.33
+	Mm
		1142038 DNJA3_MOUSE (2-395): 4.22e-117: 351: 25.98		MUSK_MOUSE (495-984): 5.85e-121: 398: 25.65
+	Hs
		169212 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		MUSK_HUMAN (486-984): 6.15e-120: 395: 25.14
+	Hs
		411469 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		411515 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		243262 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92
+	Hs
		435551 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92
+	Hs
		435729 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92