HitPredict

Interactor 1: DNJA2 (O60884)
DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14)
Gene: DNAJA2

Interactor 2: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0008284 - positive regulation of cell population proliferation GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 1367
+	Hs
		435551 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		IGF1R_HUMAN (1-1367): 0: 1387: 100.00
+	Hs
		435729 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		IGF1R_HUMAN (1-1367): 0: 1387: 100.00
+	Hs
		243254 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Hs
		411313 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Hs
		411469 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Dm
		448256 Q9VFV9_DROME (4-408): 3.25e-132: 387: 47.90		INSR_DROME (12-1356): 0: 910: 32.97
+	Hs
		243669 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12
+	Hs
		243251 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61
+	Hs
		243305 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10
+	Hs
		243277 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54
+	Hs
		243425 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16
+	Hs
		384352 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61
+	Hs
		674347 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10
+	Hs
		507875 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54
+	Hs
		681463 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16
+	Mm
		1142038 DNJA3_MOUSE (2-395): 4.22e-117: 351: 25.98		MUSK_MOUSE (993-1262): 1.48e-69: 254: 43.31
+	Hs
		385330 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61
+	Hs
		508145 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54
+	Hs
		609471 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		FGFR3_HUMAN (972-1266): 2.05e-63: 234: 38.44
+	Hs
		601821 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88