HitPredict

Interactor 1: DNJA2 (O60884)
DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14)
Gene: DNAJA2

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DnaJ~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 393
+	Hs
		243318 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		681350 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		681419 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	Sc
		412669 MAS5_YEAST (4-412): 6.79e-144: 417: 46.73		KAPA_YEAST (2-390): 2.09e-115: 343: 18.69
+	Dm
		1213393 Q9VFV9_DROME (4-408): 3.25e-132: 387: 47.90		AKT1_DROME (45-389): 1.44e-121: 366: 19.49
+	Hs
		243385 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		MP2K5_HUMAN (48-379): 4.35e-84: 265: 42.34
+	At
		187511 DNAJ3_ARATH (5-412): 6.34e-137: 399: 48.91		CIPKB_ARATH (67-372): 2.6e-110: 331: 21.66
+	Dm
		1097540 Q9VFV9_DROME (4-408): 3.25e-132: 387: 47.90		DSOR1_DROME (12-392): 4.19e-114: 340: 61.42
+	At
		1012789 Q0WN54_ARATH (8-363): 2.12e-115: 347: 35.14		MPK4_ARATH (71-393): 8.83e-127: 371: 18.98
+	Hs
		734993 DNJA3_HUMAN (2-395): 9.05e-116: 348: 26.72		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		681423 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		MP2K5_HUMAN (48-379): 4.35e-84: 265: 42.34
+	At
		1012790 Q0WN54_ARATH (8-363): 2.12e-115: 347: 35.14		MPK5_ARATH (71-393): 2.03e-121: 357: 18.07
+	At
		1012791 Q0WN54_ARATH (8-363): 2.12e-115: 347: 35.14		MPK7_ARATH (67-383): 1.52e-119: 352: 18.71
+	Hs
		243329 DNJA2_HUMAN (1-412): 1.22e-168: 480: 100.00		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	At
		1012788 Q0WN54_ARATH (8-363): 2.12e-115: 347: 35.14		MPK2_ARATH (38-376): 2.46e-115: 342: 19.25
+	Hs
		681362 DNJA1_HUMAN (4-410): 9.87e-155: 444: 54.77		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	Sc
		633044 MAS5_YEAST (4-412): 6.79e-144: 417: 46.73		MKK2_YEAST (46-361): 4.02e-55: 191: 37.50
+	Sc
		628937 SCJ1_YEAST (10-339): 1.02e-51: 179: 37.75		HOG1_YEAST (66-393): 1.71e-122: 362: 21.15
+	Hs
		805480 DJB11_HUMAN (2-355): 1.66e-108: 325: 35.85		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	Sc
		628938 SCJ1_YEAST (10-339): 1.02e-51: 179: 37.75		MKK2_YEAST (46-361): 4.02e-55: 191: 37.50