HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: RBBP7 (Q16576)
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
Gene: RBBP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	31239290, 32416067, 35987950
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1362 Hs			1 425
+	Hs
		244345 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72
+	Hs
		244257 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		RACK1_HUMAN (213-405): 2.23e-28: 115: 20.41
+	Hs
		244210 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61
+	Hs
		1017306 BPTF_HUMAN (67-161): 9.86e-11: 68.9: 41.05		RBBP7_HUMAN (1-425): 2.38e-115: 345: 100.00
+	Hs
		631433 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		TAF5_HUMAN (1-255): 1.65e-36: 143: 17.31
+	Hs
		1066968 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		TAF5_HUMAN (1-255): 1.65e-36: 143: 17.31
+	Sp
		252179 YK82_SCHPO (49-215): 1.43e-35: 147: 26.35		NLE1_SCHPO (2-152): 3.93e-32: 129: 10.90
+	Dm
		1099182 NU301_DROME (330-457): 2.51e-24: 113: 30.47		CAF1_DROME (1-209): 8.04e-42: 154: 13.16
+	Hs
		1074790 BRDT_HUMAN (26-339): 2.9e-26: 119: 19.24		TAF5_HUMAN (1-255): 1.65e-36: 143: 17.31
+	Dm
		1358857 Q9VTZ1_DROME (336-457): 5.41e-22: 105: 30.89		WDS_DROME (212-422): 1.48e-43: 157: 19.91
+	Hs
		267784 KAT2B_HUMAN (327-456): 5.61e-22: 105: 26.92		TAF5L_HUMAN (32-291): 7.24e-42: 157: 16.48
+	Hs
		267783 KAT2A_HUMAN (327-456): 1.76e-20: 100: 26.15		TAF5L_HUMAN (32-291): 7.24e-42: 157: 16.48
+	Hs
		1074799 PHIP_HUMAN (26-669): 5.56e-18: 92.9: 13.30		TAF5_HUMAN (1-255): 1.65e-36: 143: 17.31
+	Sc
		975959 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		RRB1_YEAST (234-423): 6.78e-13: 72.2: 12.15
+	Hs
		997694 BPTF_HUMAN (67-161): 9.86e-11: 68.9: 41.05		RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72
+	Mm
		903669 KMT2C_MOUSE (495-1183): 4.41e-22: 106: 13.55		WDR5_MOUSE (311-425): 1.28e-17: 85.2: 22.61
+	Hs
		903409 KAT2B_HUMAN (327-456): 5.61e-22: 105: 26.92		WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61
+	Hs
		903408 KAT2A_HUMAN (327-456): 1.76e-20: 100: 26.15		WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61