HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1362 Hs			1 126
+	Hs
		243805 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		244236 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		244752 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		241395 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		244011 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		244660 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		1066994 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H2B2F_HUMAN (1-126): 2.34e-54: 168: 97.62
+	Hs
		631389 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		631445 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		631358 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		918378 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707639 BRD3_HUMAN (37-738): 5.99e-55: 207: 47.53		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		319121 BRD1_HUMAN (197-781): 8.89e-33: 140: 13.99		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Sp
		392629 YK82_SCHPO (49-215): 1.43e-35: 147: 26.35		H2B1_SCHPO (4-125): 1.24e-45: 145: 70.49
+	Sc
		355953 RSC1_YEAST (87-841): 2.12e-39: 161: 12.50		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355988 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355564 RSC1_YEAST (87-841): 2.12e-39: 161: 12.50		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Sc
		355611 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Sc
		356020 RSC2_YEAST (87-766): 1.06e-38: 159: 13.49		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355655 RSC2_YEAST (87-766): 1.06e-38: 159: 13.49		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55