HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: SMC6 (Q96SB8)
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
Gene: SMC6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32416067
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1362 Hs			1 1091
+	Hs
		244649 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		SMC5_HUMAN (5-1069): 1.28e-69: 255: 16.18
+	Hs
		243741 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		SMC2_HUMAN (46-1069): 6.98e-59: 223: 13.19
+	Hs
		245103 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		SMC3_HUMAN (127-1042): 1.13e-48: 191: 12.77
+	Hs
		244996 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		SMC4_HUMAN (2-977): 1e-39: 162: 10.55
+	Hs
		243875 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		DESP_HUMAN (126-744): 7.41e-23: 108: 8.27
+	Hs
		244026 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		MYH10_HUMAN (472-979): 2.06e-21: 103: 10.92
+	Hs
		244025 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		MYH9_HUMAN (588-990): 2.42e-19: 96.6: 12.90
+	Hs
		631498 BRD2_HUMAN (3-737): 2.87e-55: 209: 46.43		SMC5_HUMAN (5-1069): 1.28e-69: 255: 16.18
+	Sc
		976012 GCN5_YEAST (140-462): 1.42e-41: 161: 16.37		SMC6_YEAST (42-1079): 7.72e-65: 241: 21.45
+	Hs
		1221598 PHIP_HUMAN (26-669): 5.56e-18: 92.9: 13.30		SMC5_HUMAN (5-1069): 1.28e-69: 255: 16.18
+	Hs
		1017322 BPTF_HUMAN (67-161): 9.86e-11: 68.9: 41.05		SMC5_HUMAN (5-1069): 1.28e-69: 255: 16.18
+	Hs
		1199219 PB1_HUMAN (26-956): 2.35e-19: 97.1: 10.81		SMC3_HUMAN (127-1042): 1.13e-48: 191: 12.77