HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: SIR7 (Q9NRC8)
NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
Gene: SIRT7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	30554943
Identification Methods	x-ray crystallography
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II and 1 others more... GO:0006974 - DNA damage response
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1362 Hs			1 400
+	Hs
		244666 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		244768 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94
+	Hs
		1271503 KAT2B_HUMAN (327-456): 5.61e-22: 105: 26.92		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		245018 BRD4_HUMAN (1-1362): 1.08e-121: 414: 100.00		SIR5_HUMAN (87-321): 1.97e-68: 220: 20.74
+	Hs
		1199203 PB1_HUMAN (26-956): 2.35e-19: 97.1: 10.81		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1262825 PHIP_HUMAN (26-669): 5.56e-18: 92.9: 13.30		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1017354 BPTF_HUMAN (67-161): 9.86e-11: 68.9: 41.05		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1220752 KAT2B_HUMAN (327-456): 5.61e-22: 105: 26.92		SIR2_HUMAN (75-380): 1.48e-97: 298: 21.26
+	Hs
		1199159 PB1_HUMAN (26-956): 2.35e-19: 97.1: 10.81		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1220751 KAT2A_HUMAN (327-456): 1.76e-20: 100: 26.15		SIR2_HUMAN (75-380): 1.48e-97: 298: 21.26
+	Hs
		319299 BRD1_HUMAN (197-781): 8.89e-33: 140: 13.99		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94
+	Hs
		1271483 KAT2B_HUMAN (327-456): 5.61e-22: 105: 26.92		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94
+	Hs
		1271439 KAT2A_HUMAN (327-456): 1.76e-20: 100: 26.15		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94