HitPredict

Interactor 1: OPHN1 (O60890)
Oligophrenin-1
Gene: OPHN1

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9582072
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0030036 - actin cytoskeleton organization GO:0034329 - cell junction assembly GO:0043197 - dendritic spine GO:0045198 - establishment of epithelial cell apical/basal polarity GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 193
+	Hs
		245184 OPHN1_HUMAN (1-802): 0: 650: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		245182 OPHN1_HUMAN (1-802): 0: 650: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		63073 RHG42_HUMAN (1-797): 0: 569: 50.24		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		63065 RHG42_HUMAN (1-797): 0: 569: 50.24		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		63072 RHG42_HUMAN (1-797): 0: 569: 50.24		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		901048 RHG26_HUMAN (1-661): 0: 541: 50.45		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		49631 RHG10_HUMAN (1-718): 9e-179: 534: 45.22		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		894587 RHG26_HUMAN (1-661): 0: 541: 50.45		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		49630 RHG10_HUMAN (1-718): 9e-179: 534: 45.22		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Dm
		776930 RHGF_DROME (2-801): 2.98e-149: 465: 31.01		RAC1_DROME (1-193): 2.11e-77: 231: 54.12
+	Hs
		900443 MYO9B_HUMAN (4-766): 1.5e-103: 353: 16.13		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		253337 SRGP2_HUMAN (8-800): 3.14e-106: 352: 15.27		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		436289 MYO9B_HUMAN (4-766): 1.5e-103: 353: 16.13		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		893974 MYO9B_HUMAN (4-766): 1.5e-103: 353: 16.13		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Mm
		1265268 SRGP1_MOUSE (8-793): 1.52e-101: 339: 15.79		RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48
+	Hs
		253333 SRGP2_HUMAN (8-800): 3.14e-106: 352: 15.27		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		900637 SRGP1_HUMAN (8-793): 3.25e-100: 336: 14.81		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		200213 SRGP3_HUMAN (21-795): 1.53e-100: 337: 14.49		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		915654 MYO9B_HUMAN (4-766): 1.5e-103: 353: 16.13		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Mm
		892733 SRGP1_MOUSE (8-793): 1.52e-101: 339: 15.79		CDC42_MOUSE (1-193): 5.51e-77: 230: 52.33