HitPredict

Interactor 1: OPHN1 (O60890)
Oligophrenin-1
Gene: OPHN1

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9582072
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0005737 - cytoplasm GO:0030036 - actin cytoskeleton organization GO:0043197 - dendritic spine GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 192
+	Hs
		245182 OPHN1_HUMAN (1-802): 0: 650: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		245183 OPHN1_HUMAN (1-802): 0: 650: 100.00		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		63073 RHG42_HUMAN (1-797): 0: 569: 50.24		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		63065 RHG42_HUMAN (1-797): 0: 569: 50.24		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		63072 RHG42_HUMAN (1-797): 0: 569: 50.24		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		894587 RHG26_HUMAN (1-661): 0: 541: 50.45		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		901048 RHG26_HUMAN (1-661): 0: 541: 50.45		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		49630 RHG10_HUMAN (1-718): 9e-179: 534: 45.22		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		49631 RHG10_HUMAN (1-718): 9e-179: 534: 45.22		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Dm
		776930 RHGF_DROME (2-801): 2.98e-149: 465: 31.01		RAC1_DROME (1-192): 8.65e-83: 245: 91.67
+	Hs
		253337 SRGP2_HUMAN (8-800): 3.14e-106: 352: 15.27		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		253311 SRGP2_HUMAN (8-800): 3.14e-106: 352: 15.27		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		200213 SRGP3_HUMAN (21-795): 1.53e-100: 337: 14.49		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		253333 SRGP2_HUMAN (8-800): 3.14e-106: 352: 15.27		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		893974 MYO9B_HUMAN (4-766): 1.5e-103: 353: 16.13		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		900443 MYO9B_HUMAN (4-766): 1.5e-103: 353: 16.13		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436289 MYO9B_HUMAN (4-766): 1.5e-103: 353: 16.13		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Mm
		892733 SRGP1_MOUSE (8-793): 1.52e-101: 339: 15.79		CDC42_MOUSE (1-192): 1.4e-78: 234: 70.31
+	Mm
		1265268 SRGP1_MOUSE (8-793): 1.52e-101: 339: 15.79		RHOA_MOUSE (5-192): 1.43e-77: 231: 57.98
+	Hs
		900637 SRGP1_HUMAN (8-793): 3.25e-100: 336: 14.81		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98