HitPredict

Interactor 1: OPHN1 (O60890)
Oligophrenin-1
Gene: OPHN1

Interactor 2: RHG26 (Q9UNA1)
Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (GRAF1) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26)
Gene: ARHGAP26

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BAR_3~BAR_3, BAR_3~PH, PH~PH, PH~SH3_9, RhoGAP~RhoGAP
Common GO terms	GO:0005096 - GTPase activator activity GO:0005543 - phospholipid binding GO:0007165 - signal transduction GO:0007399 - nervous system development GO:0030036 - actin cytoskeleton organization
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 802 Hs			1 814
+	Hs
		63085 RHG42_HUMAN (1-797): 0: 569: 50.24		RHG26_HUMAN (1-814): 0: 607: 100.00
+	Hs
		49644 RHG26_HUMAN (1-661): 0: 541: 50.45		RHG10_HUMAN (1-814): 1.38e-178: 534: 53.65
+	Hs
		87296 OPHN1_HUMAN (1-802): 0: 650: 100.00		C9J6V4_HUMAN (300-390): 1.75e-56: 189: 100.00
+	Hs
		63062 RHG42_HUMAN (1-797): 0: 569: 50.24		C9J6V4_HUMAN (300-390): 1.75e-56: 189: 100.00
+	Hs
		49621 RHG10_HUMAN (1-718): 9e-179: 534: 45.22		C9J6V4_HUMAN (300-390): 1.75e-56: 189: 100.00
+	Hs
		200200 SRGP2_HUMAN (8-800): 3.14e-106: 352: 15.27		SRGP3_HUMAN (21-782): 7.54e-91: 311: 13.90
+	Hs
		253374 SRGP2_HUMAN (8-800): 3.14e-106: 352: 15.27		SRGP1_HUMAN (24-773): 4.65e-86: 297: 14.63
+	Hs
		200194 SRGP3_HUMAN (21-795): 1.53e-100: 337: 14.49		SRGP3_HUMAN (21-782): 7.54e-91: 311: 13.90
+	Hs
		253290 SRGP2_HUMAN (8-800): 3.14e-106: 352: 15.27		SRGP2_HUMAN (16-774): 5.65e-84: 291: 12.63
+	Hs
		1066128 ACAP3_HUMAN (5-419): 1.8e-84: 288: 22.69		ACAP2_HUMAN (5-434): 6.2e-87: 294: 21.41
+	Hs
		1133670 RHG21_HUMAN (239-796): 4.12e-87: 304: 18.31		RHG21_HUMAN (325-784): 5.63e-75: 269: 18.24
+	Hs
		200223 SRGP3_HUMAN (21-795): 1.53e-100: 337: 14.49		RHG24_HUMAN (248-724): 1.23e-63: 229: 17.65
+	Hs
		957808 RHG04_HUMAN (20-789): 3.95e-91: 308: 14.89		RHG04_HUMAN (17-732): 6.21e-70: 250: 13.52
+	Hs
		64723 RHG24_HUMAN (246-798): 2.26e-87: 294: 17.95		RHG32_HUMAN (338-740): 1.15e-71: 259: 21.41
+	Hs
		1231269 RHG24_HUMAN (246-798): 2.26e-87: 294: 17.95		RHG24_HUMAN (248-724): 1.23e-63: 229: 17.65