Interactor 1: NBN (O60934)
Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1)
Gene: NBN

Interactor 2: TOPB1 (Q92547)
DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)
Gene: TOPBP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 17765870, 27590578
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains BRCT~BRCT, BRCT~PTCB-BRCT
Common GO terms GO:0000077 - DNA damage checkpoint signaling
GO:0000724 - double-strand break repair via homologous recombination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0007095 - mitotic G2 DNA damage checkpoint signaling
and 8 others

more...

Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 754
Hs

1 1522
+ Xl
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024