HitPredict

Interactor 1: O61380 (O61380)
Eukaryotic translation initiation factor 4G1, isoform A (Eukaryotic translation initiation factor 4G1, isoform C) (FI02056p) (Translation initiation factor eIF4G)
Gene: eIF4G1

Interactor 2: Q9VRY0 (Q9VRY0)
eIF-4F 25 kDa subunit
Gene: eIF4E4

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	27374989, 15804566
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000340 - RNA 7-methylguanosine cap binding GO:0003743 - translation initiation factor activity GO:0006413 - translational initiation GO:0016281 - eukaryotic translation initiation factor 4F complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1666 Dm			1 229
+	Dm
		247402 O61380_DROME (1-1666): 0: 1160: 100.00		IF4E_DROME (11-229): 9.44e-98: 286: 61.54
+	Dm
		247418 O61380_DROME (1-1666): 0: 1160: 100.00		Q9VSB6_DROME (1-229): 1.5e-94: 278: 51.29
+	Dm
		247426 O61380_DROME (1-1666): 0: 1160: 100.00		Q9W5B3_DROME (51-229): 6.32e-90: 273: 59.44
+	Dm
		247420 O61380_DROME (1-1666): 0: 1160: 100.00		Q9VSG1_DROME (24-229): 1.48e-91: 270: 45.63
+	Hs
		203332 IF4G3_HUMAN (89-1660): 0: 668: 20.51		IF4E_HUMAN (31-229): 1.67e-97: 285: 47.03
+	Mm
		926371 IF4G1_MOUSE (2-1660): 0: 650: 20.79		IF4E_MOUSE (27-229): 5.31e-99: 288: 46.60
+	Hs
		416970 IF4G1_HUMAN (15-1660): 0: 647: 21.72		IF4E_HUMAN (31-229): 1.67e-97: 285: 47.03
+	Hs
		416966 IF4G2_HUMAN (704-1660): 0: 643: 19.22		IF4E_HUMAN (31-229): 1.67e-97: 285: 47.03
+	Mm
		926373 IF4G3_MOUSE (25-1660): 0: 633: 19.25		IF4E_MOUSE (27-229): 5.31e-99: 288: 46.60
+	Dm
		820453 Q9VCH1_DROME (2-1636): 5.37e-158: 533: 18.79		IF4E_DROME (11-229): 9.44e-98: 286: 61.54
+	Dm
		1362929 Q9VCH1_DROME (2-1636): 5.37e-158: 533: 18.79		Q9W5B3_DROME (51-229): 6.32e-90: 273: 59.44
+	Dm
		1362918 Q9VCH1_DROME (2-1636): 5.37e-158: 533: 18.79		Q9VSG1_DROME (24-229): 1.48e-91: 270: 45.63
+	At
		138595 IF4G2_ARATH (575-1342): 1.9e-122: 404: 16.39		IF4E4_ARATH (37-217): 7.98e-74: 224: 32.63
+	Ce
		78134 B5BM23_CAEEL (458-1361): 3.39e-97: 341: 15.20		IF4E3_CAEEL (24-229): 1.19e-88: 263: 38.50
+	At
		1275774 IF4G1_ARATH (622-1340): 5.01e-102: 348: 16.96		IF4E5_ARATH (52-221): 1.61e-78: 236: 33.33
+	At
		138598 IF4G1_ARATH (622-1340): 5.01e-102: 348: 16.96		IF4E4_ARATH (37-217): 7.98e-74: 224: 32.63
+	Sc
		424870 IF4F2_YEAST (281-1103): 4.18e-90: 317: 17.76		IF4E_YEAST (25-219): 5.63e-67: 207: 32.67
+	Sc
		424869 IF4F1_YEAST (302-1096): 1.91e-72: 265: 17.17		IF4E_YEAST (25-219): 5.63e-67: 207: 32.67
+	Hs
		237144 ANR17_HUMAN (1-558): 4.72e-16: 86.8: 7.71		IF4E2_HUMAN (13-220): 3.27e-83: 249: 32.72