HitPredict

Interactor 1: VAB1 (O61460)
Ephrin receptor 1 (EC 2.7.10.1) (Tyrosine-protein kinase Eph receptor) (Variable abnormal protein 1)
Gene: vab-1

Interactor 2: Q19475 (Q19475)
Ephrin RBD domain-containing protein
Gene: efn-3

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	10635316
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005886 - plasma membrane GO:0007411 - axon guidance
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1122 Ce			1 211
+	Hs
		856508 EPHA5_HUMAN (4-1081): 0: 1040: 29.08		EFNB2_HUMAN (2-158): 4.48e-68: 213: 29.01
+	Hs
		856595 EPHA5_HUMAN (4-1081): 0: 1040: 29.08		EFNA5_HUMAN (1-148): 8.1e-50: 163: 19.39
+	Ce
		247480 VAB1_CAEEL (1-1122): 0: 986: 100.00		Q9U3M2_CAEEL (6-169): 2.82e-65: 202: 31.55
+	Ce
		106791 VAB1_CAEEL (1-1122): 0: 986: 100.00		G5EEE7_CAEEL (8-155): 1.2e-52: 172: 31.82
+	Ce
		219533 VAB1_CAEEL (1-1122): 0: 986: 100.00		EFN4_CAEEL (2-163): 2.38e-50: 168: 26.98
+	Hs
		665459 EPHA8_HUMAN (31-1101): 0: 964: 28.04		EFNA5_HUMAN (1-148): 8.1e-50: 163: 19.39
+	Hs
		665458 EPHA8_HUMAN (31-1101): 0: 964: 28.04		EFNA4_HUMAN (4-164): 9.27e-50: 162: 25.00
+	Mm
		856591 EPHA4_MOUSE (25-1104): 0: 854: 22.11		EFNB2_MOUSE (2-158): 8.34e-69: 215: 29.63
+	Hs
		595985 EPHA4_HUMAN (25-1104): 0: 851: 22.02		EFNA1_HUMAN (1-188): 1.71e-71: 217: 25.00
+	Hs
		856510 EPHA4_HUMAN (25-1104): 0: 851: 22.02		EFNB2_HUMAN (2-158): 4.48e-68: 213: 29.01
+	Hs
		872403 EPHB3_HUMAN (28-1096): 0: 836: 23.06		EFNB1_HUMAN (5-168): 6.08e-70: 218: 31.74
+	Hs
		856507 EPHB3_HUMAN (28-1096): 0: 836: 23.06		EFNB2_HUMAN (2-158): 4.48e-68: 213: 29.01
+	Hs
		872654 EPHA4_HUMAN (25-1104): 0: 851: 22.02		EFNB3_HUMAN (23-166): 7.89e-59: 189: 27.27
+	Dr
		47564 A0A8M9PHF0_DANRE (6-1097): 0: 834: 21.87		EFNB2_DANRE (3-163): 2.13e-63: 201: 25.90
+	Hs
		872405 EPHB3_HUMAN (28-1096): 0: 836: 23.06		EFNB3_HUMAN (23-166): 7.89e-59: 189: 27.27
+	Hs
		856597 EPHA4_HUMAN (25-1104): 0: 851: 22.02		EFNA5_HUMAN (1-148): 8.1e-50: 163: 19.39
+	Hs
		856348 EPHA4_HUMAN (25-1104): 0: 851: 22.02		EFNA4_HUMAN (4-164): 9.27e-50: 162: 25.00
+	Dr
		47531 A0A8M9PHF0_DANRE (6-1097): 0: 834: 21.87		A0A8M1Q1X6_DANRE (17-186): 2.37e-51: 167: 22.10
+	Mm
		139054 Q8BRB1_MOUSE (9-1102): 0: 834: 21.88		EFNA5_MOUSE (20-148): 1.01e-49: 162: 20.71
+	Hs
		217636 EPHA4_HUMAN (25-1104): 0: 851: 22.02		EFNA2_HUMAN (20-129): 1.01e-42: 144: 19.20