HitPredict

Interactor 1: VAB1 (O61460)
Ephrin receptor 1 (EC 2.7.10.1) (Tyrosine-protein kinase Eph receptor) (Variable abnormal protein 1)
Gene: vab-1

Interactor 2: Q95PW9 (Q95PW9)
NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family
Gene: nck-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	22383893
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0016310 - phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1122 Ce			1 395
+	Hs
		557643 EPHA5_HUMAN (4-1081): 0: 1040: 29.08		NCK1_HUMAN (2-394): 6.74e-80: 252: 37.78
+	Hs
		208997 EPHA8_HUMAN (31-1101): 0: 964: 28.04		NCK2_HUMAN (2-393): 1.95e-85: 266: 37.31
+	Hs
		872422 EPHA5_HUMAN (4-1081): 0: 1040: 29.08		GRB2_HUMAN (5-175): 1.72e-28: 112: 20.37
+	Hs
		655284 EPHA5_HUMAN (4-1081): 0: 1040: 29.08		P85A_HUMAN (270-393): 4.44e-20: 94.5: 19.69
+	Hs
		412104 EPHA5_HUMAN (4-1081): 0: 1040: 29.08		FYN_HUMAN (6-244): 7.07e-19: 90.2: 12.45
+	Hs
		129252 EPHA5_HUMAN (4-1081): 0: 1040: 29.08		P85B_HUMAN (281-394): 1.24e-18: 89.8: 22.22
+	Hs
		209018 EPHA4_HUMAN (25-1104): 0: 851: 22.02		NCK2_HUMAN (2-393): 1.95e-85: 266: 37.31
+	Hs
		665467 EPHA8_HUMAN (31-1101): 0: 964: 28.04		GRB2_HUMAN (5-175): 1.72e-28: 112: 20.37
+	Hs
		655221 EPHA8_HUMAN (31-1101): 0: 964: 28.04		P85A_HUMAN (270-393): 4.44e-20: 94.5: 19.69
+	Hs
		412037 EPHA8_HUMAN (31-1101): 0: 964: 28.04		FYN_HUMAN (6-244): 7.07e-19: 90.2: 12.45
+	Hs
		129210 EPHA8_HUMAN (31-1101): 0: 964: 28.04		P85B_HUMAN (281-394): 1.24e-18: 89.8: 22.22
+	Hs
		665469 EPHA8_HUMAN (31-1101): 0: 964: 28.04		BTK_HUMAN (2-129): 2.59e-11: 67.1: 17.05
+	Hs
		872630 EPHA4_HUMAN (25-1104): 0: 851: 22.02		GRB2_HUMAN (5-175): 1.72e-28: 112: 20.37
+	Hs
		655285 EPHA4_HUMAN (25-1104): 0: 851: 22.02		P85A_HUMAN (270-393): 4.44e-20: 94.5: 19.69
+	Mm
		763386 EPHA4_MOUSE (25-1104): 0: 854: 22.11		FYN_MOUSE (6-244): 6.88e-19: 90.2: 12.45
+	Hs
		412105 EPHA4_HUMAN (25-1104): 0: 851: 22.02		FYN_HUMAN (6-244): 7.07e-19: 90.2: 12.45
+	Hs
		129253 EPHA4_HUMAN (25-1104): 0: 851: 22.02		P85B_HUMAN (281-394): 1.24e-18: 89.8: 22.22
+	Hs
		412103 EPHB3_HUMAN (28-1096): 0: 836: 23.06		FYN_HUMAN (6-244): 7.07e-19: 90.2: 12.45
+	Hs
		522871 EPHA4_HUMAN (25-1104): 0: 851: 22.02		SRC_HUMAN (43-217): 1.14e-12: 71.3: 16.95
+	Mm
		403425 EPHB2_MOUSE (31-1099): 0: 832: 21.43		SRC_MOUSE (43-180): 9.38e-12: 68.3: 21.58