HitPredict

Interactor 1: KCC2D (O62305)
Calcium/calmodulin-dependent protein kinase type II (CaM kinase II) (EC 2.7.11.17) (Uncoordinated protein 43)
Gene: unc-43

Interactor 2: KCC2D (O62305)
Calcium/calmodulin-dependent protein kinase type II (CaM kinase II) (EC 2.7.11.17) (Uncoordinated protein 43)
Gene: unc-43

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.888

The method score is based on:

Property Details
Experiments 19123269, 20139983, 21343908
Identification Methods two hybrid, x-ray crystallography, enzymatic study, molecular sieving, light scattering, two hybrid array, two hybrid pooling approach
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CaMKII_AD~CaMKII_AD, CaMKII_AD~Pkinase, Pkinase~Pkinase
Common GO terms GO:0000165 - MAPK cascade
GO:0004683 - calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
and 10 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 720
Ce

1 720
+ Hs
+ Hs
+ Hs
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+ Hs
+ Hs
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+ At
+ At
+ Rn
+ At
+ Hs

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Last updated: 15 Jul 2024