HitPredict

Interactor 1: O62530 (O62530)
Adaptor protein complex 2, mu subunit, isoform A (Adaptor protein complex 2, mu subunit, isoform B) (Adaptor protein complex 2, mu subunit, isoform C) (Clathrin-associated adaptor complex AP-2 medium chain) (Clathrin-associated protein) (SD05403p)
Gene: AP-2mu

Interactor 2: Q9VDC3 (Q9VDC3)
AP complex subunit sigma
Gene: AP-2sigma

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Adap_comp_sub~Clat_adaptor_s, Clat_adaptor_s~Clat_adaptor_s
Common GO terms	GO:0006886 - intracellular protein transport GO:0006897 - endocytosis GO:0030122 - AP-2 adaptor complex GO:0035615 - clathrin adaptor activity GO:0072583 - clathrin-dependent endocytosis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 437 Dm			1 142
+	Hs
		903691 AP2M1_HUMAN (1-437): 4.91e-178: 506: 86.79		AP1S1_HUMAN (1-142): 1.95e-51: 162: 45.07
+	Hs
		880423 AP2M1_HUMAN (1-437): 4.91e-178: 506: 86.79		AP1S2_HUMAN (2-142): 4.11e-51: 161: 46.81
+	Hs
		880428 AP1M1_HUMAN (2-436): 2.74e-177: 503: 39.59		AP1S2_HUMAN (2-142): 4.11e-51: 161: 46.81
+	Hs
		1287472 AP2M1_HUMAN (1-437): 4.91e-178: 506: 86.79		AP1S3_HUMAN (1-142): 1.17e-49: 157: 43.66
+	Hs
		1299170 AP1M1_HUMAN (2-436): 2.74e-177: 503: 39.59		AP1S3_HUMAN (1-142): 1.17e-49: 157: 43.66
+	Hs
		1315736 AP1M1_HUMAN (2-436): 2.74e-177: 503: 39.59		AP1M2_HUMAN (2-142): 2.73e-44: 151: 20.14
+	Hs
		864097 AP2M1_HUMAN (1-437): 4.91e-178: 506: 86.79		AP2S1_HUMAN (1-142): 4.85e-46: 148: 95.78
+	Mm
		915560 AP2M1_MOUSE (1-437): 4.91e-178: 506: 86.79		AP2S1_MOUSE (1-142): 4.85e-46: 148: 95.78
+	Hs
		1287458 AP2M1_HUMAN (1-437): 4.91e-178: 506: 86.79		AP2M1_HUMAN (1-138): 1.51e-41: 144: 15.22
+	Hs
		903697 AP1M2_HUMAN (2-436): 7.01e-170: 484: 37.53		AP1S1_HUMAN (1-142): 1.95e-51: 162: 45.07
+	Hs
		880436 AP1M2_HUMAN (2-436): 7.01e-170: 484: 37.53		AP1S2_HUMAN (2-142): 4.11e-51: 161: 46.81
+	Hs
		1299174 AP1M2_HUMAN (2-436): 7.01e-170: 484: 37.53		AP1S3_HUMAN (1-142): 1.17e-49: 157: 43.66
+	At
		187811 AP2M_ARATH (2-437): 1.11e-164: 472: 46.62		AP2S_ARATH (1-142): 1.23e-44: 144: 59.86
+	Sc
		961954 AP1M1_YEAST (1-436): 3.14e-150: 436: 34.66		AP1M1_YEAST (1-139): 7.91e-42: 146: 17.14
+	Sc
		715577 AP1M1_YEAST (1-436): 3.14e-150: 436: 34.66		AP1S1_YEAST (2-142): 2.74e-42: 139: 40.56
+	Hs
		1267501 AP3M1_HUMAN (1-436): 5.75e-127: 375: 24.44		AP3S1_HUMAN (1-142): 4.26e-51: 162: 40.54
+	Hs
		887150 AP3M1_HUMAN (1-436): 5.75e-127: 375: 24.44		AP3S2_HUMAN (1-142): 3.1e-49: 158: 37.84
+	Sc
		959833 AP2M_YEAST (1-436): 8.37e-125: 372: 31.11		AP2S_YEAST (2-142): 1.34e-45: 147: 48.28
+	Sc
		961968 AP2M_YEAST (1-436): 8.37e-125: 372: 31.11		AP1M1_YEAST (1-139): 7.91e-42: 146: 17.14