HitPredict

Interactor 1: AURKB (O70126)
Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
Gene: AURKB

Interactor 2: H33 (P84244)
Histone H3.3
Gene: H3-3a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16179389
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000775 - chromosome, centromeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 345 Mm			1 136
+	Hs
		935379 AURKC_HUMAN (52-344): 1.05e-136: 392: 75.43		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		682163 AKT2_HUMAN (37-342): 1.88e-133: 390: 30.41		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		160506 AURKA_HUMAN (1-339): 2.92e-132: 384: 56.56		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		610712 KAPCB_HUMAN (43-337): 1.36e-132: 383: 28.33		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		160599 AURKA_HUMAN (1-339): 2.92e-132: 384: 56.56		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		610715 KAPCB_HUMAN (43-337): 1.36e-132: 383: 28.33		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		610742 KAPCB_HUMAN (43-337): 1.36e-132: 383: 28.33		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Mm
		952738 AURKA_MOUSE (6-343): 5.13e-131: 381: 59.17		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Hs
		935110 AURKB_HUMAN (1-345): 1.4e-130: 378: 84.06		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952545 AURKB_HUMAN (1-345): 1.4e-130: 378: 84.06		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		1086273 AURKB_HUMAN (1-345): 1.4e-130: 378: 84.06		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		1174628 AURKB_HUMAN (1-345): 1.4e-130: 378: 84.06		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Dm
		356080 Q27393_DROME (7-337): 2.59e-127: 372: 50.75		H3_DROME (1-136): 5.32e-59: 180: 97.06
+	Hs
		1157219 AURKB_HUMAN (1-345): 1.4e-130: 378: 84.06		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Hs
		828423 AURKC_HUMAN (52-344): 1.05e-136: 392: 75.43		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	At
		886668 AUR1_ARATH (58-345): 1.43e-123: 358: 58.62		H31_ARATH (1-136): 1.05e-58: 179: 94.85
+	Hs
		828344 AURKB_HUMAN (1-345): 1.4e-130: 378: 84.06		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Dm
		356113 AURKB_DROME (75-334): 3.22e-93: 282: 50.00		H3_DROME (1-136): 5.32e-59: 180: 97.06
+	Sc
		758807 IPL1_YEAST (75-335): 2.66e-78: 245: 46.95		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Sc
		730798 IPL1_YEAST (75-335): 2.66e-78: 245: 46.95		CENPA_YEAST (18-134): 3.39e-40: 135: 56.67