HitPredict

Interactor 1: LNX1 (O70263)
E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb protein X 1) (Ligand of Numb-binding protein 1) (Numb-binding protein 1) (RING-type E3 ubiquitin transferase LNX)
Gene: LNX1

Interactor 2: NUMB (Q9QZS3)
Protein numb homolog (m-Nb) (m-Numb)
Gene: NUMB

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	9535908
Identification Methods	affinity chromatography technology, far western blotting
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PDZ~PID
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Mm			1 653
+	Hs
		833629 LNX1_HUMAN (1-728): 2.56e-131: 407: 87.57		NUMB_HUMAN (1-653): 2.26e-92: 301: 93.26
+	Hs
		833625 LNX2_HUMAN (5-728): 2.59e-111: 354: 45.77		NUMB_HUMAN (1-653): 2.26e-92: 301: 93.26
+	Mm
		1265184 LNX2_MOUSE (4-728): 1.69e-87: 291: 38.25		NUMB_MOUSE (1-653): 3.86e-96: 311: 100.00
+	Hs
		1252574 LNX1_HUMAN (1-728): 2.56e-131: 407: 87.57		NUMBL_HUMAN (1-653): 3.95e-45: 171: 46.10
+	Hs
		1115807 LNX1_HUMAN (1-728): 2.56e-131: 407: 87.57		Q49AR9_HUMAN (8-268): 1.25e-36: 146: 16.67
+	Hs
		1252371 LNX1_HUMAN (1-728): 2.56e-131: 407: 87.57		ANS1A_HUMAN (8-248): 3.97e-35: 144: 18.18
+	Hs
		269170 LNX1_HUMAN (1-728): 2.56e-131: 407: 87.57		DAB1_HUMAN (31-624): 1.03e-31: 132: 15.63
+	Mm
		140100 LNX2_MOUSE (4-728): 1.69e-87: 291: 38.25		NUMBL_MOUSE (1-653): 1.6e-43: 167: 45.79
+	Hs
		833631 PARD3_HUMAN (131-652): 4.36e-20: 97.8: 12.59		NUMB_HUMAN (1-653): 2.26e-92: 301: 93.26
+	Rn
		957050 GRIP1_RAT (227-597): 2.67e-37: 152: 18.35		Q3MUI2_RAT (1-653): 3.6e-48: 180: 45.79
+	Hs
		1377729 GRIP1_HUMAN (131-464): 5.32e-26: 116: 18.97		NUMBL_HUMAN (1-653): 3.95e-45: 171: 46.10
+	Hs
		253559 SCRIB_HUMAN (230-597): 2.22e-32: 137: 20.10		CAPON_HUMAN (8-281): 3.01e-35: 141: 17.41
+	Mm
		1143393 DLG4_MOUSE (578-726): 1.86e-21: 101: 19.21		ANS1B_MOUSE (7-212): 4.6e-41: 163: 18.84
+	Mm
		1143409 DLG4_MOUSE (578-726): 1.86e-21: 101: 19.21		Q8BZM2_MOUSE (7-212): 3.66e-43: 163: 18.84
+	Mm
		957153 PARD3_MOUSE (206-469): 1.02e-30: 131: 21.52		DAB2_MOUSE (5-624): 6.49e-30: 127: 15.39
+	Mm
		1143503 DLG4_MOUSE (578-726): 1.86e-21: 101: 19.21		CAPON_MOUSE (8-288): 2.84e-38: 150: 18.12
+	Mm
		887083 DLG4_MOUSE (578-726): 1.86e-21: 101: 19.21		ANS1A_MOUSE (8-248): 2e-33: 139: 18.60
+	Mm
		1143433 DLG4_MOUSE (578-726): 1.86e-21: 101: 19.21		SYNJ1_MOUSE (288-650): 3.26e-09: 62.5: 11.56
+	Rn
		677795 DLG4_RAT (578-726): 1.67e-21: 101: 19.21		M3K11_RAT (465-646): 3.77e-09: 62: 21.39
+	Mm
		88458 DLG4_MOUSE (578-726): 1.86e-21: 101: 19.21		D3Z656_MOUSE (285-650): 5.27e-09: 61.7: 9.41