Interactor 1: PRGC1 (O70343)
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha)
Gene: Ppargc1a
Interactor 2: SIR1 (Q923E4)
NAD-dependent protein deacetylase sirtuin-1 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (SIR2alpha) (Sir2) (mSIR2a) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: Sirt1
Species: Mus musculus
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.74 | 0.60 | 0.669 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 15744310, 15716268 |
| Identification Methods | pull down, affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, deacetylase assay |
| Interaction Type | direct interaction, physical association, association, deacetylation reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0000785 - chromatin GO:0000791 - euchromatin GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 7 others more... |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
