HitPredict

Interactor 1: SP3 (O70494)
Transcription factor Sp3
Gene: SP3

Interactor 2: HDAC2 (P70288)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) (YY1 transcription factor-binding protein)
Gene: HDAC2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16109738
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0017053 - transcription repressor complex GO:0045892 - negative regulation of DNA-templated transcription and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 783 Mm			1 488
+	Hs
		970932 SP3_HUMAN (1-783): 1.86e-173: 520: 94.91		HDAC2_HUMAN (1-488): 0: 707: 99.39
+	Mm
		140208 SP3_MOUSE (1-783): 0: 546: 100.00		HDAC1_MOUSE (1-446): 0: 647: 89.46
+	Hs
		970913 SP3_HUMAN (1-783): 1.86e-173: 520: 94.91		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Hs
		435149 SP1_HUMAN (34-780): 1.16e-133: 417: 36.26		HDAC2_HUMAN (1-488): 0: 707: 99.39
+	Mm
		140212 SP1_MOUSE (31-780): 6.38e-135: 420: 35.88		HDAC1_MOUSE (1-446): 0: 647: 89.46
+	Hs
		435085 SP1_HUMAN (34-780): 1.16e-133: 417: 36.26		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Hs
		1038377 ZN273_HUMAN (236-782): 9.29e-119: 371: 12.79		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Hs
		177170 SP1_HUMAN (34-780): 1.16e-133: 417: 36.26		HDAC3_HUMAN (10-431): 0: 575: 58.02
+	Mm
		292670 SP1_MOUSE (31-780): 6.38e-135: 420: 35.88		Q9JM08_MOUSE (10-431): 0: 569: 57.78
+	Hs
		1110303 SP6_HUMAN (599-705): 2.16e-44: 166: 70.54		HDAC2_HUMAN (1-488): 0: 707: 99.39
+	Hs
		1046724 KLF5_HUMAN (616-707): 4.83e-27: 117: 58.70		HDAC2_HUMAN (1-488): 0: 707: 99.39
+	Hs
		157899 KLF11_HUMAN (616-711): 3.07e-32: 133: 60.42		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Mm
		140295 Q8BPQ2_MOUSE (609-705): 5.71e-28: 117: 53.61		HDAC1_MOUSE (1-446): 0: 647: 89.46
+	Hs
		1038360 KLF5_HUMAN (616-707): 4.83e-27: 117: 58.70		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Hs
		1032214 KLF1_HUMAN (600-705): 3.06e-27: 115: 51.89		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Hs
		177338 SP7_HUMAN (602-705): 9.58e-44: 165: 71.96		HDAC3_HUMAN (10-431): 0: 575: 58.02
+	Hs
		1193248 ZSCA2_HUMAN (184-711): 1.75e-88: 293: 13.04		HDAC8_HUMAN (33-372): 1.01e-137: 403: 43.40
+	Hs
		177364 KLF6_HUMAN (609-705): 2.6e-29: 120: 53.61		HDAC3_HUMAN (10-431): 0: 575: 58.02
+	Mm
		1207125 Q8BPQ2_MOUSE (609-705): 5.71e-28: 117: 53.61		Q9JM08_MOUSE (10-431): 0: 569: 57.78
+	Hs
		1260184 KLF16_HUMAN (621-705): 5.69e-36: 138: 65.88		HDAC7_HUMAN (29-280): 2.88e-23: 105: 26.37