HitPredict

Interactor 1: SNF1 (O74536)
SNF1-like protein kinase ssp2 (EC 2.7.11.1)
Gene: ssp2

Interactor 2: AAKB (P78789)
5'-AMP-activated protein kinase subunit beta (AMPK subunit beta)
Gene: amk2

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	17289942, 22375066, 19371376
Identification Methods	x-ray crystallography, affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	AMPK1_CBM~AdenylateSensor, AMPKBI~AdenylateSensor, AMPK1_CBM~Pkinase, AMPKBI~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010514 - induction of conjugation with cellular fusion GO:0031588 - nucleotide-activated protein kinase complex and 1 others more... GO:0061762 - CAMKK-AMPK signaling cascade
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 576 Sp			1 298
+	At
		1105393 KIN10_ARATH (33-573): 1.07e-164: 480: 39.42		KINB2_ARATH (1-297): 1.87e-100: 297: 26.45
+	At
		955250 KIN11_ARATH (33-573): 1.23e-160: 470: 37.79		KINB2_ARATH (1-297): 1.87e-100: 297: 26.45
+	Hs
		871508 AAPK2_HUMAN (20-568): 2.93e-146: 434: 36.56		AAKB1_HUMAN (53-296): 7.45e-102: 300: 31.15
+	Hs
		1025246 AAPK1_HUMAN (12-557): 1.37e-145: 433: 36.61		AAKB1_HUMAN (53-296): 7.45e-102: 300: 31.15
+	Hs
		212375 AAPK2_HUMAN (20-568): 2.93e-146: 434: 36.56		AAKB2_HUMAN (1-296): 9.18e-101: 297: 29.10
+	Mm
		1125558 AAPK1_MOUSE (12-557): 1.29e-144: 431: 36.25		AAKB1_MOUSE (53-296): 2.85e-101: 299: 31.15
+	Hs
		212403 AAPK1_HUMAN (12-557): 1.37e-145: 433: 36.61		AAKB2_HUMAN (1-296): 9.18e-101: 297: 29.10
+	Sc
		419851 SNF1_YEAST (14-573): 8.31e-159: 469: 45.08		SIP2_YEAST (52-297): 6.27e-84: 260: 28.62
+	Rn
		871249 AAPK1_RAT (12-557): 8.24e-146: 434: 36.43		AAKB1_RAT (53-296): 5.8e-100: 295: 30.74
+	At
		1105332 KIN10_ARATH (33-573): 1.07e-164: 480: 39.42		KINB1_ARATH (1-296): 1.26e-72: 226: 20.76
+	Ce
		1280174 AAPK2_CAEEL (11-540): 2.68e-146: 437: 39.81		Q9XUY2_CAEEL (56-296): 1.89e-87: 264: 27.11
+	Ce
		1280172 AAPK2_CAEEL (11-540): 2.68e-146: 437: 39.81		Q9NAH7_CAEEL (53-296): 7.24e-86: 260: 26.81
+	At
		955198 KIN11_ARATH (33-573): 1.23e-160: 470: 37.79		KINB1_ARATH (1-296): 1.26e-72: 226: 20.76
+	Sc
		419961 SNF1_YEAST (14-573): 8.31e-159: 469: 45.08		GAL83_YEAST (52-297): 1.31e-66: 215: 28.38
+	At
		1105350 KIN10_ARATH (33-573): 1.07e-164: 480: 39.42		SNF4_ARATH (85-261): 6.17e-50: 173: 21.43
+	At
		955218 KIN11_ARATH (33-573): 1.23e-160: 470: 37.79		SNF4_ARATH (85-261): 6.17e-50: 173: 21.43
+	Zm
		1164295 Q6RXY1_MAIZE (31-573): 2.7e-153: 451: 38.39		Q9FUY5_MAIZE (75-200): 6.74e-42: 152: 24.24
+	At
		1105410 KIN10_ARATH (33-573): 1.07e-164: 480: 39.42		KINB3_ARATH (191-297): 7.82e-31: 113: 24.77
+	At
		955261 KIN11_ARATH (33-573): 1.23e-160: 470: 37.79		KINB3_ARATH (191-297): 7.82e-31: 113: 24.77