HitPredict

Interactor 1: ERF3 (O74718)
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3) (ERF3) (EC 3.6.5.-) (ERF2) (Polypeptide release factor 3) (Translation release factor 3)
Gene: sup35

Interactor 2: DOM34 (Q9USL5)
Protein dom34
Gene: DOM34

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.804

Property	Details
Experiments	9701287, 10376874
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	GTP_EFTU~eRF1_1, GTP_EFTU~eRF1_2, GTP_EFTU_D3~eRF1_2, GTP_EFTU_D3~eRF1_3
Common GO terms	GO:0002184 - cytoplasmic translational termination GO:0003747 - translation release factor activity GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 662 Sp			1 390
+	Hs
		1310745 HBS1L_HUMAN (31-662): 9.4e-176: 518: 34.89		PELO_HUMAN (1-385): 3.1e-158: 451: 48.31
+	Hs
		90294 D9YZV0_HUMAN (31-662): 9.4e-176: 518: 34.89		PELO_HUMAN (1-385): 3.1e-158: 451: 48.31
+	Mm
		1149110 HBS1L_MOUSE (31-662): 5.54e-170: 503: 34.39		PELO_MOUSE (1-385): 3.89e-158: 451: 47.01
+	Hs
		914547 ERF3B_HUMAN (97-661): 9.15e-175: 513: 43.21		ERF1_HUMAN (2-388): 2.35e-128: 377: 15.03
+	Hs
		545815 ERF3A_HUMAN (178-661): 7.47e-174: 506: 47.59		ERF1_HUMAN (2-388): 2.35e-128: 377: 15.03
+	Sc
		402857 ERF3_YEAST (46-662): 4.39e-165: 490: 49.20		ERF1_YEAST (2-390): 8.19e-119: 353: 16.86
+	Sc
		367665 EF1A_YEAST (234-660): 1.4e-163: 478: 37.61		ERF1_YEAST (2-390): 8.19e-119: 353: 16.86
+	Dm
		820840 HBS1_DROME (146-660): 7.37e-99: 318: 36.40		PELO_DROME (1-371): 1.24e-154: 443: 50.14