HitPredict

Interactor 1: MITF (O75030)
Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32)
Gene: MITF

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	11709556, 16029420
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 628
+	Mm
		222296 MITF_MOUSE (1-526): 1.14e-125: 379: 94.49		PIAS3_MOUSE (1-628): 0: 867: 96.98
+	Hs
		252892 MITF_HUMAN (1-526): 1.36e-125: 379: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		1016123 SRBP2_HUMAN (71-464): 3.48e-49: 184: 16.43		PIAS3_HUMAN (1-628): 0: 879: 100.00
+	Hs
		252893 MITF_HUMAN (1-526): 1.36e-125: 379: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278069 SRBP2_HUMAN (71-464): 3.48e-49: 184: 16.43		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278272 SRBP2_HUMAN (71-464): 3.48e-49: 184: 16.43		PIAS2_HUMAN (1-550): 0: 651: 59.00