HitPredict

Interactor 1: LRP3 (O75074)
Low-density lipoprotein receptor-related protein 3 (LRP-3) (105 kDa low-density lipoprotein receptor-related protein) (hLRp105)
Gene: LRP3

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 903
+	Hs
		253910 LRP3_HUMAN (1-770): 2.04e-129: 405: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		253886 LRP3_HUMAN (1-770): 2.04e-129: 405: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		1190283 LRP10_HUMAN (43-769): 9.55e-67: 236: 37.30		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		804318 NOTC1_HUMAN (209-703): 1.58e-16: 86.9: 8.96		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		270320 LRP6_HUMAN (397-489): 1.93e-12: 73.2: 38.54		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1205571 LRAD3_HUMAN (171-249): 7.74e-11: 66.2: 43.04		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Mm
		57546 LRAD3_MOUSE (171-249): 6.52e-11: 66.6: 43.04		ITCH_MOUSE (1-903): 0: 885: 91.16
+	Mm
		966330 NOTC1_MOUSE (30-563): 2.33e-10: 66.5: 7.68		ITCH_MOUSE (1-903): 0: 885: 91.16
+	Hs
		804337 NOTC1_HUMAN (209-703): 1.58e-16: 86.9: 8.96		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		1205572 LRAD3_HUMAN (171-249): 7.74e-11: 66.2: 43.04		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		1327941 LRP12_HUMAN (5-332): 3.99e-10: 65.4: 8.40		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		804323 NOTC1_HUMAN (209-703): 1.58e-16: 86.9: 8.96		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Dm
		247208 TENM_DROME (501-711): 1.05e-11: 71.1: 7.44		NEDD4_DROME (3-901): 0: 720: 29.95
+	Hs
		804164 NOTC1_HUMAN (209-703): 1.58e-16: 86.9: 8.96		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		808178 LRAD3_HUMAN (171-249): 7.74e-11: 66.2: 43.04		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Dm
		247320 TENM_DROME (501-711): 1.05e-11: 71.1: 7.44		Q9W325_DROME (496-903): 1.26e-168: 499: 46.38
+	Hs
		253919 LRP3_HUMAN (1-770): 2.04e-129: 405: 100.00		HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34
+	Dm
		246947 TENM_DROME (501-711): 1.05e-11: 71.1: 7.44		SMUF1_DROME (16-518): 1.15e-39: 161: 16.19