HitPredict

Interactor 1: ROCK2 (O75116)
Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)
Gene: ROCK2

Interactor 2: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30442766, 30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras, Ras~Rho_Binding
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1388 Hs			1 189
+	Hs
		254430 ROCK2_HUMAN (1-1388): 0: 768: 100.00		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		254429 ROCK2_HUMAN (1-1388): 0: 768: 100.00		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		254466 ROCK2_HUMAN (1-1388): 0: 768: 100.00		RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88
+	Hs
		254463 ROCK2_HUMAN (1-1388): 0: 768: 100.00		RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52
+	Hs
		350143 ROCK1_HUMAN (18-1383): 0: 667: 64.67		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		1035173 ROCK1_HUMAN (18-1383): 0: 667: 64.67		RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71
+	Hs
		348647 ROCK1_HUMAN (18-1383): 0: 667: 64.67		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00
+	Hs
		349292 ROCK1_HUMAN (18-1383): 0: 667: 64.67		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		895066 ROCK1_HUMAN (18-1383): 0: 667: 64.67		RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52
+	Hs
		349329 STK38_HUMAN (74-417): 6.46e-76: 261: 40.21		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		914081 STK38_HUMAN (74-417): 6.46e-76: 261: 40.21		RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88
+	Hs
		349671 LATS2_HUMAN (64-390): 2.8e-66: 247: 36.90		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		350237 MRCKA_HUMAN (685-1313): 1.42e-55: 215: 12.70		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		1070238 MRCKA_HUMAN (685-1313): 1.42e-55: 215: 12.70		RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71
+	Hs
		348715 MRCKA_HUMAN (685-1313): 1.42e-55: 215: 12.70		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00
+	Hs
		349389 MRCKA_HUMAN (685-1313): 1.42e-55: 215: 12.70		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		914124 MRCKA_HUMAN (685-1313): 1.42e-55: 215: 12.70		RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88
+	Hs
		895123 MRCKA_HUMAN (685-1313): 1.42e-55: 215: 12.70		RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52
+	Hs
		350729 MRCKB_HUMAN (721-1313): 4.08e-46: 184: 12.17		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		349030 MRCKB_HUMAN (721-1313): 4.08e-46: 184: 12.17		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00