HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30415952
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 454
+	Hs
		347021 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		348286 MYH15_HUMAN (5-865): 1.8e-37: 155: 11.03		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		346088 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		346089 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		346097 MYH11_HUMAN (563-983): 2.12e-18: 93.6: 10.66		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		345843 DESP_HUMAN (233-945): 1.26e-09: 64.9: 14.36		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Mm
		1125394 BRE1A_MOUSE (1-1000): 4.02e-64: 236: 56.59		SRBP1_MOUSE (172-453): 4.45e-35: 140: 16.61
+	Hs
		379070 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		379071 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		378986 DESP_HUMAN (233-945): 1.26e-09: 64.9: 14.36		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40