HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	31152661, 33868474, 34795231, 38580884, 19410543
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003730 - mRNA 3'-UTR binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031625 - ubiquitin protein ligase binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 393
+	Hs
		386898 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386212 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		387710 MYH13_HUMAN (493-982): 2.93e-16: 86.3: 6.99		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		387815 MYH4_HUMAN (567-982): 2.09e-15: 83.6: 9.20		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		148271 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386037 DESP_HUMAN (233-945): 1.26e-09: 64.9: 14.36		P53_HUMAN (1-393): 0: 619: 100.00