HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: H2A1B (P04908)
Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)
Gene: H2AC4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	37633270
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006325 - chromatin organization
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 130
+	Hs
		1138171 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		H2A2A_HUMAN (1-130): 2.9e-68: 203: 96.92
+	Hs
		391741 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00
+	Hs
		1087019 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39
+	Sc
		392585 BRE1_YEAST (506-1000): 2.2e-57: 212: 18.77		H2A2_YEAST (16-128): 1.02e-59: 181: 79.65
+	Sc
		392215 BRE1_YEAST (506-1000): 2.2e-57: 212: 18.77		H2A1_YEAST (16-127): 9.92e-53: 164: 80.36
+	Hs
		391578 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00
+	Hs
		728498 MYH11_HUMAN (563-983): 2.12e-18: 93.6: 10.66		H2A1C_HUMAN (1-130): 3.23e-68: 203: 98.46
+	Hs
		148317 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46
+	Hs
		148937 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		H2A2A_HUMAN (1-130): 2.9e-68: 203: 96.92
+	Hs
		148983 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		H2A3_HUMAN (1-130): 3.34e-68: 203: 99.23
+	Hs
		149144 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		H2A1C_HUMAN (1-130): 3.23e-68: 203: 98.46
+	Hs
		148275 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00
+	Hs
		148390 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		H2A1D_HUMAN (1-130): 3.77e-68: 202: 99.23
+	Hs
		149187 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		H2A1A_HUMAN (1-130): 2.93e-67: 201: 92.37
+	Hs
		149019 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		H2A2B_HUMAN (1-130): 8.97e-67: 199: 93.85
+	Hs
		148877 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39
+	Hs
		149235 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		H2AJ_HUMAN (1-126): 2.23e-65: 196: 94.44
+	Hs
		148361 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06