HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane GO:0031625 - ubiquitin protein ligase binding GO:0042803 - protein homodimerization activity
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 724
+	Hs
		256202 BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		437945 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431590 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		148301 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431480 MYH7_HUMAN (1-380): 1.19e-11: 71.3: 11.54		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		148295 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Sc
		366973 BRE1_YEAST (506-1000): 2.2e-57: 212: 18.77		HSP82_YEAST (12-724): 0: 927: 61.26
+	Sc
		544495 BRE1_YEAST (506-1000): 2.2e-57: 212: 18.77		HSC82_YEAST (13-724): 0: 922: 60.22
+	Sc
		365862 USO1_YEAST (204-945): 1.35e-10: 68: 14.95		HSP82_YEAST (12-724): 0: 927: 61.26
+	Hs
		148349 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		ENPL_HUMAN (3-693): 0: 917: 46.44