HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: ISL1 (P61371)
Insulin gene enhancer protein ISL-1 (Islet-1)
Gene: ISL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31186351
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 349
+	Mm
		899940 BRE1B_MOUSE (1-1001): 6.52e-75: 268: 92.51		ISL1_MOUSE (1-349): 1.96e-89: 274: 100.00
+	Hs
		899922 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		ISL1_HUMAN (1-349): 1.96e-89: 274: 100.00
+	Mm
		899941 BRE1A_MOUSE (1-1000): 4.02e-64: 236: 56.59		ISL1_MOUSE (1-349): 1.96e-89: 274: 100.00
+	Hs
		150533 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		ABLM1_HUMAN (2-339): 4.04e-22: 99.7: 12.87
+	Hs
		148128 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		ABLM1_HUMAN (2-339): 4.04e-22: 99.7: 12.87