HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25416956, 32296183
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 158
+	Hs
		256237 BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00		UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07
+	Hs
		256296 BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00		Q7KZS0_HUMAN (1-137): 2.27e-71: 214: 100.00
+	Hs
		256229 BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00		UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12
+	Hs
		256227 BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00		UBE2A_HUMAN (1-154): 3.37e-67: 202: 41.56
+	Hs
		256239 BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00		UBE2B_HUMAN (1-154): 1.37e-66: 201: 41.56
+	Hs
		919748 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07
+	At
		639386 BRE1A_ARATH (497-1000): 3.93e-99: 334: 23.12		UBC1_ARATH (1-149): 3.05e-33: 116: 40.94
+	At
		790156 BRE1A_ARATH (497-1000): 3.93e-99: 334: 23.12		UBC2_ARATH (1-149): 1.2e-32: 115: 40.27
+	Hs
		851821 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12
+	Hs
		829017 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		UBE2A_HUMAN (1-154): 3.37e-67: 202: 41.56
+	Hs
		927757 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		UBE2B_HUMAN (1-154): 1.37e-66: 201: 41.56
+	Hs
		724763 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Sp
		251716 BRL2_SCHPO (646-1000): 1.91e-60: 221: 21.23		UBC2_SCHPO (1-149): 1.08e-31: 112: 42.28
+	Sc
		410240 BRE1_YEAST (506-1000): 2.2e-57: 212: 18.77		UBC2_YEAST (1-154): 2.21e-29: 107: 40.26
+	Ce
		712245 BRE1_CAEEL (25-799): 1.9e-14: 79.9: 15.44		UBC2_CAEEL (4-157): 4.4e-74: 220: 35.71
+	Ce
		712246 BRE1_CAEEL (25-799): 1.9e-14: 79.9: 15.44		UBC1_CAEEL (1-154): 4.52e-68: 206: 40.26
+	Sp
		618356 BRL1_SCHPO (504-1000): 9.54e-26: 116: 18.57		UBC2_SCHPO (1-149): 1.08e-31: 112: 42.28
+	At
		639387 BRE1B_ARATH (38-843): 1.3e-15: 83.9: 12.39		UBC1_ARATH (1-149): 3.05e-33: 116: 40.94
+	At
		790157 BRE1B_ARATH (38-843): 1.3e-15: 83.9: 12.39		UBC2_ARATH (1-149): 1.2e-32: 115: 40.27