HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042803 - protein homodimerization activity GO:0043005 - neuron projection
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 2527
+	Hs
		1130168 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130714 MYH2_HUMAN (291-983): 3.18e-32: 138: 9.47		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		724862 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		725175 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		148910 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		551732 DESP_HUMAN (233-945): 1.26e-09: 64.9: 14.36		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Mm
		1130117 MYH9_MOUSE (694-982): 4.73e-11: 69.3: 12.46		LRRK2_MOUSE (1-2527): 0: 2865: 86.09