HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: BRE1A (Q5VTR2)
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
Gene: RNF20

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 0.60 0.762

The method score is based on:

Property Details
Experiments 25533843, 27557628, 33961781, 35271311, 37071682, 22155569, 21362549, 19410543, 24441044, 27569044, 29507117, 30649429, 35235311, 21329877, 16307923
Identification Methods affinity chromatography technology, cross-linking study, pull down, biochemical, anti tag coimmunoprecipitation, chromatography technology, molecular sieving
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0003730 - mRNA 3'-UTR binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
and 5 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 1001
Hs

1 975
+ At
+ At
+ Hs
+ Hs
+ Sc
+ Os
+ Hs
+ Hs
+ Dm
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024