HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: CDC73 (Q6P1J9)
Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)
Gene: CDC73

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	22021426
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 531
+	Hs
		1138172 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		CDC73_HUMAN (1-531): 0: 824: 100.00
+	Hs
		724878 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		CDC73_HUMAN (1-531): 0: 824: 100.00
+	Hs
		148949 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		CDC73_HUMAN (1-531): 0: 824: 100.00
+	Hs
		551743 DESP_HUMAN (233-945): 1.26e-09: 64.9: 14.36		CDC73_HUMAN (1-531): 0: 824: 100.00