HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: Q7KZS0 (Q7KZS0)
SUMO-conjugating enzyme UBC9 (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I)
Gene: UBE2I

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	25416956, unassigned1304
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0005634 - nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 184
+	At
		639386 BRE1A_ARATH (497-1000): 3.93e-99: 334: 23.12		UBC1_ARATH (1-155): 1.01e-67: 205: 36.13
+	At
		790156 BRE1A_ARATH (497-1000): 3.93e-99: 334: 23.12		UBC2_ARATH (1-155): 7.74e-68: 205: 35.48
+	Hs
		256237 BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00		UB2D2_HUMAN (4-157): 4.47e-74: 220: 32.47
+	Hs
		256240 BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Hs
		256227 BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00		UBE2A_HUMAN (1-157): 1.19e-68: 207: 36.31
+	Hs
		256239 BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00		UBE2B_HUMAN (1-155): 1.06e-67: 205: 36.13
+	Hs
		919748 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		UB2D2_HUMAN (4-157): 4.47e-74: 220: 32.47
+	Hs
		829017 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		UBE2A_HUMAN (1-157): 1.19e-68: 207: 36.31
+	Hs
		927757 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		UBE2B_HUMAN (1-155): 1.06e-67: 205: 36.13
+	Hs
		724763 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Sp
		251716 BRL2_SCHPO (646-1000): 1.91e-60: 221: 21.23		UBC2_SCHPO (1-137): 8.21e-27: 100: 41.61
+	Sc
		410240 BRE1_YEAST (506-1000): 2.2e-57: 212: 18.77		UBC2_YEAST (1-137): 1.13e-25: 98.6: 41.61
+	Ce
		712245 BRE1_CAEEL (25-799): 1.9e-14: 79.9: 15.44		UBC2_CAEEL (4-157): 4.73e-74: 220: 33.12
+	At
		639387 BRE1B_ARATH (38-843): 1.3e-15: 83.9: 12.39		UBC1_ARATH (1-155): 1.01e-67: 205: 36.13
+	At
		790157 BRE1B_ARATH (38-843): 1.3e-15: 83.9: 12.39		UBC2_ARATH (1-155): 7.74e-68: 205: 35.48
+	Ce
		712246 BRE1_CAEEL (25-799): 1.9e-14: 79.9: 15.44		UBC1_CAEEL (1-171): 5.48e-67: 204: 32.75
+	Sp
		618356 BRL1_SCHPO (504-1000): 9.54e-26: 116: 18.57		UBC2_SCHPO (1-137): 8.21e-27: 100: 41.61