HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: CC146 (Q8IYE0)
Coiled-coil domain-containing protein 146
Gene: CCDC146

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.50	0.523

Property	Details
Experiments	25416956
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 955
+	Hs
		148200 BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00		CTRO_HUMAN (278-871): 2.3e-17: 90.1: 12.69
+	Hs
		724686 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		MYH9_HUMAN (129-949): 1.25e-44: 178: 12.09
+	Hs
		724687 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		MYH10_HUMAN (293-954): 1.18e-34: 145: 10.46
+	Hs
		528356 MYH6_HUMAN (461-982): 5.68e-20: 98.6: 9.77		MYH6_HUMAN (91-948): 6.54e-40: 162: 10.76
+	Dm
		404213 MYSA_DROME (2-686): 3.65e-25: 115: 10.22		MYSA_DROME (150-946): 3.46e-34: 144: 11.87
+	Hs
		502901 MYH6_HUMAN (461-982): 5.68e-20: 98.6: 9.77		MYH3_HUMAN (6-815): 2.53e-35: 148: 11.47
+	Hs
		725095 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		MYH10_HUMAN (293-954): 1.18e-34: 145: 10.46
+	Hs
		148460 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		CTRO_HUMAN (278-871): 2.3e-17: 90.1: 12.69
+	Hs
		528435 MYH8_HUMAN (461-982): 6.23e-20: 98.6: 9.39		MYH4_HUMAN (377-954): 1.64e-26: 119: 9.56
+	Rn
		361106 MYH6_RAT (461-982): 7.77e-20: 98.2: 9.77		MYH6_RAT (461-954): 7.59e-22: 104: 10.10
+	Hs
		724943 MYH9_HUMAN (271-982): 5.38e-32: 137: 10.53		MY18A_HUMAN (362-872): 3.44e-09: 63.4: 13.67
+	Hs
		528432 MYH8_HUMAN (461-982): 6.23e-20: 98.6: 9.39		MYH13_HUMAN (489-954): 7.47e-20: 98.2: 9.21
+	Hs
		725097 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		MYH11_HUMAN (503-949): 2.44e-18: 93.2: 8.95
+	Hs
		725179 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		CP135_HUMAN (145-911): 1.3e-17: 90.4: 11.89
+	Hs
		148461 MYH10_HUMAN (1-443): 3.14e-19: 96.3: 12.58		CTRO_HUMAN (278-871): 2.3e-17: 90.1: 12.69
+	Hs
		148466 MYH11_HUMAN (563-983): 2.12e-18: 93.6: 10.66		CTRO_HUMAN (278-871): 2.3e-17: 90.1: 12.69