HitPredict

Interactor 1: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Interactor 2: WAC (Q9BTA9)
WW domain-containing adapter protein with coiled-coil
Gene: WAC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.708

Property	Details
Experiments	33961781, 35271311, 28514442, 21329877
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 647
+	Hs
		1138213 BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49		WAC_HUMAN (1-647): 4.1e-106: 336: 100.00
+	Dm
		116047 BRE1_DROME (9-758): 2.45e-13: 76.6: 10.22		M9PHE3_DROME (134-646): 7.32e-31: 131: 19.86
+	Hs
		148573 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		SC24C_HUMAN (250-545): 2.11e-28: 123: 20.83
+	Hs
		149481 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		PCLO_HUMAN (107-640): 3.8e-10: 65.7: 10.38
+	Hs
		148818 CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91		MDC1_HUMAN (251-632): 1.66e-09: 63.3: 11.65